LIPID NANOPARTICLES

DELIVERY SYSTEMS

LIPID NANOPARTICLES

Cargo

  • Nucleic acidsL RNA(e.g. mRNA, siRNA) and DNA

Functions

  • Protein production or replacement (mRNA)
  • Gene expression control (siRNA)
  • Gene editing (CRISPR-Cas9)
  • RNA or DNA vaccines

Characteristics

  • Optimized formulation based on liposome technology
  • Transfection upon internalization by target cells
  • Surface modification to change in vivo biodistribution
  • Administration route: IV, IM, SC

Lipid Nanoparticles (LNP) are innovative delivery systems that contain RNA or DNA molecules combined with lipids to enable precise and effective delivery of genetic material to target cells and tissues.
LNPs can encapsulate diverse cargos, including messenger RNA (mRNA), small interference RNA (siRNA), microRNA (miRNA), circular RNA (circRNA), guide RNA (gRNA), plasmid DNA (pDNA) and antisense oligomers (ASO’s). Their versatility provides a large variety of application options for both preclinical research and translation to the clinic.

LNPs have garnered significant attention in the scientific and medical communities as a prominent technology platform that enables the delivery of nucleic acids to prevent and treat various diseases. LNP formulation technology allowed the rapid development of the COVID-19 vaccines, and now many more LNP formulations are in clinical trials for the treatment of infectious diseases, cancer, and genetic disorders.

At LIPOSOMA we are serving researchers with LNP technology solutions tailored for in vivo, in vitro and in situ applications. With our scientific expertise, we can help you in advancing your research and realizing your medical aims, whether vaccine development or other medical applications. For more information about LNP custom manufacturing contact our business development department.